MyBioSource.com's MARCH1 Antibody (Center) is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, and Western Blot. The MARCH1 Antibody (Center) was generated using MAR1, MARCH1, and RTL1 as the antigen and it reacts with Human, and Mouse.
Description
MARCH1 is a member of the MARCH family of membrane-bound
E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin
(see MIM 191339) to target lysines in substrate proteins, thereby
signaling their vesicular transport between membrane compartments.
MARCH1 downregulates the surface expression of major
histocompatibility complex (MHC) class II molecules (see MIM
142880) and other glycoproteins by directing them to the late
endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed
14722266]; Thibodeau et al., 2008 [PubMed 18389477]; De Gassart et
al., 2008 [PubMed 18305173])